Jco Destination Problem

I had created a Jco Destination when I test it I get the following:

com.sap.mw.jco.JCO$Exception: (102) RFC_ERROR_COMMUNICATION: Connect to SAP gateway failed Connect_PM TYPE=A ASHOST=r3qa2 SYSNR=00 GWHOST=r3qa2 GWSERV=sapgw00 PCS=1 LOCATION CPIC (TCP/IP) on local host ERROR partner not reached (host r3qa2, service sapgw00) TIME Fri Jul 22 15:24:14 2005 RELEASE 640 COMPONENT NI (network interface) VERSION 37 RC -10 MODULE

What be can this?