Regarding setup table and initialisation

Hello Experts ,

In Our system , I have activated 2LIS_11_V_SCL in R/3 side transported till Quality . Now we are planning to move to production .

However other datasources in component 11 like 2LIS_11_VAITM and 2LIS_11_VAHDR are already in production since 5 yrs delta is going on .

My query is , when I am filling set up table for 2LIS_11_V_SCL, Will dataflow (DELTA ) of datasource 2LIS_11_VAITM and 2LIS_11_VAHDR impacted ?

Means , Do I need to delete data from data targets belongs to datasource 2LIS_11_VAITM and 2LIS_11_VAHDR ,again I will have to laod data with datasource 2LIS_11_V_SCL .

Kindly Suggest .