Error calling transaction from R/3

Whenever u try to pull certain I-view like under ESS > Income tax provisional statement then the portal throws below mentioned error. Portal is not able to call transactions from R/3.

Error:

The requested URL could not be retrieved

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While trying to retrieve the URL: http://dev.mglep.com:26000/sap(ZT0yZElaRG5xNDlZdFF4aGcyTDhzMWxRLS1hVUR5bDBMbjBDZ2hWUUcyMlZmcmlBLS0=)/bc/gui/sap/its/webgui?

The following error was encountered:

Connection to 69.43.161.156 Failed

The system returned:

(111) Connection refusedThe remote host or network may be down. Please try the request again.

Your cache administrator is root.

Please help