Unable to open Integration Builder (SXMB_IFR)

Hello Experts,

I am getting error while running the tcode sxmb_ifr

"Error while reading configuration for secure communication.".

However when I do SLDCHECK then I can login to SLD, RFC connection SAPSLDAPI and LCRSAPRFC are also working fine.

Only problem I can see is connection to HTTP destination INTEGRATION_DIRECTORY_HMI is showing internal error , however as per post installtion if response is 500 then its ok. Will it be a problem?

Any suggestion/ help how I can fix the issue.

I have gone through the blogs and forum related to that I dont find the solution yet most of things mentioned in the forums are already verfied.

Thanks,

Pushkar