we have encounterd following error for Mail interface in Production Server and message is in System Erro status in Seeburger Adapter Engine,
2011-02-10 13:31:42 Error Mail: error occured: java.net.ConnectException: Connection timed out
2011-02-10 13:31:42 Error Mail: error occured: com.sap.aii.af.lib.mp.module.ModuleException
2011-02-10 13:31:42 Error Adapter Framework caught exception: Failed to call the endpoint
2011-02-10 13:31:42 Error Delivering the message to the application using connection Mail_http://sap.com/xi/XI/System failed, due to: com.sap.engine.interfaces.messaging.api.exception.MessagingException: com.sap.aii.af.sdk.xi.srt.BubbleException: Failed to call the endpoint [null "null"]; nested exception caused by: java.net.ConnectException: Connection timed out.
2011-02-10 13:31:42 Error The message status was set to NDLV.
Please advise what can be done.