error when creating rfc

Error Details Error when opening an RFC connection

Error Details ERROR: partner 'wc40-alt.medialogik.com:sapgw01' not reached

Error Details LOCATION: SAP-Gateway on host sapdev / sapgw03

Error Details ERROR TEXT: WSAECONNREFUSED: Connection refused

Error Details RELEASE: 700

i am getting these type of errors what was the problem.. can u help me..