As Eddy pointed out, to deactivate tax option in A/P would only disable user to select different Tax codes. However, this tax code must not be empty if their tax status are liable. You need to set up default tax code.
You can't "disable" the tax calculation as it is handled based on the internal SAP Business One tax engine (code) and from the tax code setup. If you do not want to calculate tax, you can setup a tax code such as "EXEMPT" and set the code to zero. When tax is that calculated for an invoice it will always be zero.
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