whenever i atart the application server i got error message , help me

• ERROR file opened at 20090622 115300 India Standard Time, SAP-REL 710,0,51 RFC-VER 3 913191 MT-SL

T:3132 Error in program 'mmc': ======> SAP_CMINIT3 : rc=20 > Connect to SAP gateway failed

Connect_PM GWHOST=ksp-7c40406dab9, GWSERV=sapgw00, SYSNR=00

LOCATION CPIC (TCP/IP) on local host with Unicode

ERROR partner 'ksp-7c40406dab9:3300' not reached

TIME Mon Jun 22 11:53:00 2009

RELEASE 710

COMPONENT NI (network interface)

VERSION 39

RC -10

MODULE nixxi.cpp

LINE 3068

DETAIL NiPConnect2: 172.31.254.254:3300

SYSTEM CALL connect

ERRNO 10061

ERRNO TEXT WSAECONNREFUSED: Connection refused

COUNTER 1

>TS> Mon Jun 22 11:53:53 2009

T:3132 Error in program 'mmc': ======> SAP_CMINIT3 : rc=20 > Connect to SAP gateway failed

Connect_PM GWHOST=ksp-7c40406dab9, GWSERV=sapgw00, SYSNR=00

LOCATION CPIC (TCP/IP) on local host with Unicode

ERROR partner 'ksp-7c40406dab9:3300' not reached

TIME Mon Jun 22 11:53:53 2009

RELEASE 710

COMPONENT NI (network interface)

VERSION 39

RC -10

MODULE nixxi.cpp

LINE 3068

DETAIL NiPConnect2: 172.31.254.254:3300

SYSTEM CALL connect

ERRNO 10061

ERRNO TEXT WSAECONNREFUSED: Connection refused

COUNTER 2

>TS> Mon Jun 22 11:54:11 2009

T:3132 Error in program 'mmc': ======> SAP_CMINIT3 : rc=20 > Connect to SAP gateway failed

Connect_PM GWHOST=ksp-7c40406dab9, GWSERV=sapgw00, SYSNR=00

LOCATION CPIC (TCP/IP) on local host with Unicode

ERROR partner 'ksp-7c40406dab9:3300' not reached

TIME Mon Jun 22 11:54:11 2009

RELEASE 710

COMPONENT NI (network interface)

VERSION 39

RC -10

MODULE nixxi.cpp

LINE 3068

DETAIL NiPConnect2: 172.31.254.254:3300

SYSTEM CALL connect

ERRNO 10061

ERRNO TEXT WSAECONNREFUSED: Connection refused

COUNTER 3