After Refresh of Test System XI connection is not working

We are using SRM 4.0 in ECS and recently did a refresh to our Quality system. After the refresh we went through the normal post refresh activities and assumed that everything was ok. We started creating test shopping carts and PO for XML vendors and nothing is going out through XI. I have ran tcode sxmb_moni to check to see if any error message are occuring but there are no messages in the system.

We have restarted the server but can't seem to get anything to go out through XML.

Can anyone provide any information or some things to check?