Error code 401:"HTTP_RESP_STATUS_CODE_NOT_OK"

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Hi Experts,

Messages are failed in SXMB_MONI with the Error code 401:"HTTP_RESP_STATUS_CODE_NOT_OK"

Text message "Unauthorised".

-->No users was locked & All users are maintaining perfect roles, no password problem.

2.Messages are processing successfully from Adapter Engine to Integration Engine and after executing all the pipeline steps through XI adapter the messages are sending to receiver successfully (File to XI Adapter)

3.But in the case of Integration Engine(After executing all the pipeline steps) to Adapter Engine the messages are failed with the above error code (XI to File Adapter).

and also can any body tell me what is the JRFC Function module which is executing in between these two.

Can any body give me the solution ASAP.

Thanks & Regards

Sankar