Changing running FB campaign

Business requirement is following:

create a campaign to send out emails;

create a campaign for FB custom audience;

those who have opened an email sent from a first campaign, should be excluded from the FB campaign dynamically.

.

As I see this can be achieved by creating an email campaign and sending out emails. Then I have to create a new target group for the same target group as a in former campaign, but also adding in the segmentation email campaign id and interaction type "EMAIL_OPENED" for exclusion.

I would execute an FB campaign and would send a custom audience to the FB.

.

How can I dynamically (periodically) refresh the FB custom audience? I can change a target group in the running campaign, but can I stop the campaign, refresh target group and execute the campaign to send updated custom audience to the FB?

Any ideas?