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How to solve the Error : Could not open connection in EO1 System

I am working inSupport project in second level, where we were used to handle the tickets.

here my Case is : Sender is sending(PO_CENTRAL) messages to receiver(ARIBA) via EO1 system where we are getting a below error.

Error text:

The message could not be transferred to endpoint via connection SOAP_http: // because of: SOAP: Response message contains an errorXIAdapter / PARSING / ADAPTER.SOAP_EXCEPTION - soap fault: org.springframework.orm.jpa.JpaSystemException: Could not open connection; nested exception is org.hibernate.exception.GenericJDBCException: Could not open connection


where lot of messages were failing in EO1 system.

kindly suggest how to solve the issue.

Waiting for responses.

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