Sender Channel getting problem "RFCSenderR3 "

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Hello friends,

In my XI QA env...there is one service "RFCSenderR3" which is not showing any messages like in message monitoring ,but if i check in Communication channel CC monitoring for that service it shows as following error :

Error*

Sender channel 'RFCSenderR3' for party ",service'RQ1'

ERROR can not instantiate RfcPoolException:error initializing

RfcServerPool:com.sap.aii.af.rfc.core.repository.RfcRepositoryException:can not connect to destination system due to :com.sap.mw.jco.JCO$Exception:(103) RFC_ERROR_LOGON_FAILURE:Mandante 101

Here RQ1 is the R3 reciever system.

And i have checked rfc connection from R3 end which shows it is fine..

Can any one suggest me and help me ,exactly what should i need to be checked to solve this problem .

Thank you