Meta Data JCo Error

Hi All,

I am Created Application JCo's it is successfully tested then i created Metadata JCo then i tested and i got the following Error.

com.sap.mw.jco.JCO$Exception: (102) RFC_ERROR_COMMUNICATION: Connect to message server host failed Connect_PM TYPE=B MSHOST=ptgsap10 GROUP=PUBLIC R3NAME=EC6 MSSERV=sapmsEC6 PCS=1 LOCATION CPIC (TCP/IP) on local host with Unicode ERROR partner 'ptgsap10:sapmsEC6' not reached TIME Thu Jul 19 19:20:00 2007 RELEASE 700 COMPONENT NI (network interface) VERSION 38 RC -10 MODULE nixxi.cpp LINE 2764 DETAIL NiPConnect2 SYSTEM CALL connect ERRNO 10061 ERRNO TEXT WSAECONNREFUSED: Connection refused COUNTER 3

How to Rectify this Error?

Thaks and Regards,

Phanikumar.