Daniel,
Since you asked about the impact on /usr/sap/trans of having multiple systems installed on the same host, that is precisely what Atul responded with.
As an FYI, if you want Atul to be notified of your response, you need to comment/reply directly to his answer. He won't be notified otherwise. In a similar vein, if you respond directly to my answer, I'll be notified, but if you just respond with another answer to your own question, no one else will be notified.
With regard to hostctrl, it shouldn't matter.
With regard to /usr/sap, you'll notice that each installation creates its own <SID> subfolder under that, so again, you should be able to have multiple installations on the same host, even of different releases. However, in this circumstance, if you don't intend each system to be part of the same transport domain, then you need to take care of /usr/sap/trans in the manner described in the document that Atul linked. In other words, he did answer you.
Cheers,
Matt
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