DBCDriverException: SAP DBTech JDBC: Cannot connect to jdbc

DBCDriverException: SAP DBTech JDBC: Cannot connect to jdbc

DB in 20.172.x4x.xx8

Application in 20.x5.x7.xx

S/4 HANA installation JDBC Error. i am able to login HANA Studio. & if Application & DB in Same Host Means . No Error occur.

if Application and DB in different Host Means Error Occur .