Sequence dependent setup activity question

To do sequence dependent setup activity, I need to create setup group/key and matrix. once I do that, I can use schedule sequence heuristic and sort my orders based on setup. so I can use normal heurictics to consider setup times from the matrix and perform setup dependent scheduling..

But I have read some comments in the forum that we need to use PPDS optimization to consider setup times and optimize the schedule..

My question is,

what functionality do I get when I use schedule sequence button (and sort by setup) in rescheduling function Versus PPDS optimizer?