The variants in OB52 are at the compamy code level. You can take these down to GL account level, customer, vendor and materials. If you can segrgate based on that you have your control.
Being more creative, you might be able to build some special validation that reads a custom table and if there is a period xx for business area xxx then it gives a message. Totally custom and I would not do this unless I absolutely could not use standard stuff.
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