Number of Locks and MSA

I am asking a question here in which I think I know the answer but I will reach out to the community for clarification anyways.

I recently added an MSA Server to a warm standby replication system and I have had two separate systems run out of locks on the PRIMARY database server. Both systems have not had new code applied nor have it had new jobs in place. The only thing I would say that is new about the environment is that we had added an MSA

I would say that I expect the amount of required locks to be more on the target systems but on the primary I don't expect that we need to increase the locks due to replication.

Have anyone had a similar experience before? Is it possible that replication (MSA in this case) would require additional locks on the primary. Just so you know we increased locks from 500000 to 1000000. Target systems were always 1000000, including MSA target

Thanks