Trouble send a message to XI via Proxy

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Hi,

I'm trying to send a message from R/3 System to XI via Proxy, but I just can see the message in the R/3 side (SXMB_MONI), the message has a Green Flag Status. When I activated a queue that the message belongs to it goes to Red Flag Status and I got an 'ErrorHeader' with:

- http://sap.com/exchange/MessageFormat">

<SAP:Context />

<SAP:Code p1="401" p2="Unauthorized" p3="" p4="">HTTP.HTTP_STATUS_CODE_NEQ_OK</SAP:Code>

<SAP:Text language="EN">HTTP status code 401 : Unauthorized</SAP:Text>

</SAP:ErrorHeader>

When I check a Compoment Monitoring:

<b>domain

Integration Server

Integration Engines

Proxy Runtime <Business System></b>

I got an error 'Unable to log on to system <Business System> in language en with user XIRWBUSER'.

Could someone help me?

Thanks in advance

Leo