RFC connection between SAP R/3 and BIZTALK

Hi, I am abap technical Consultant. I am trying to make an RFC connection between SAP R/3 and Non SAP middle ware system (BIZTALK). in Sm59 , i am making TCP/IP connection and assign one program id. when i test the connection in SM59 , it throws an error saying "Program id is not registred". I want to know that do i need to register this program id at SAP level? If yes , pls send me the steps .